04.06.01 Chemical sciences (analytical chemistry 02.00.02)
ELECTROCHEMICAL SENSORY SYSTEMS FOR THE DETERMINATION OF A VARIETY OF ORGANIC AND INorganic Compounds
Scientific direction:
Enzymeless electrochemical methods, sensors / immunosensors for solving specific analytical problems related to the determination of organic compounds, including diagnostic value.
Studied aspects:
· Development of theoretical ideas about the mechanism of functioning of enzyme-free electrochemical sensors and immunosensors and methodological approaches to their creation;
· Obtaining new knowledge of physicochemical, including redox, properties of new synthesized substances;
· Determination of possible mechanisms of drug action and creation of a new voltammetric method for quantitative determination of the main substance in substances and dosage forms on the basis of research results.
The most striking scientific results:
· A new scientific direction has been formed, which is important for the creation of means of electrochemical diagnostics according to vital indicators;
· Algorithms and devices have been developed and patented for the quantitative determination of the causative agent of infectious diseases, as well as the control of some important biochemical parameters;
· Studies have been conducted to study the electrochemical performance of 5-methyl-6-X-7-oxo-1,2,4-triazolo [1,5-a] pyrimidinides, probable flow patterns have been proposed;
· Developed a volt-amperometric analyzer “ElSens” for determining a wide range of compounds of organic and non-limited nature. Produced industrial party.
Career opportunities: internship opportunities at leading universities in Russia, Europe, USA, China; participation in Russian and international conferences; participation in the implementation of Russian and international grants; scholarships of foreign funds jointly with Russia, the first President of Russia B. N. Yeltsin, as well as the President of the Russian Federation, the Government of the Russian Federation, the Governor of the Sverdlovsk Region.
Additional requirements of the supervisor:
· Basic chemical education
· Knowledge of English
Main publications:
· Electrochemical immunosensor for diagnosis of the forest-spring encephalitis / K.Z. Brainina, A.N. Kositzina, M.Yu. Rubtsova, B.M. Sergeev, S.Yu. Saraeva // Comprehensive Analytical Chemistry. – 2007. – V. 49. – P. е265 – е269.
· Catalytic systems based on organic complexes of nickel (II) in chronoamperometric determination of urea and creatinine / A.N. Kozitsina, J.V. Shalygina, S.S. Dedeneva, G.L. Rusinov, S.G. Thickness, E.V. Verbitsky, Kh.Z. Brainin // Izv. RAS. Ser. chemical - 2009. - № 6. - p. 1091 - 1097.
· Hybrid electrochemical magnetic assay for Salmonella Typhimurium detection / Kh.Z. Brainina, A.N. Kozitsina, Y.A. Glazyrina // IEEE Sensors journal. – 2010. – V. 10. – №11. – P. 1699 – 1704.
· Enzyme-free electrochemical method for the determination of E. coli using Fe3O4 nanocomposites with a ferrocene-modified SiO2 shell / A.N. Kozitsina, N.N. Malysheva, I.A. Utepova, Yu.A. Glazyrina, A.I. Matern, H.Z. Brainina, O.N. Chupakhin // Zhurn. analytical chemistry. - 2015. - T. 70. - № 5. - p. 476 - 483
· A. New enzyme-free electrochemical immunoassay for Escherichia Coli detection using magnetic nanoparticles / A. Kozitsina, T. Svalova, N. Malysheva, Y. Glazyrina, A. Matern // Analytical letters. – 2016. – V. 49. – Is. 2. – P. 245 – 257.
· Amperometric detection of cholesterol using cobalt (II) chloride as an electrocatalyst in aprotic media / A.N. Kozitsina, A.V. Okhokhonin, A.I. Matern // Journal of Electroanalytical Chemistry. – 2016. – V. 772. – P. 89 – 95.
· Biomolecular Release from Alginate-Modified Electrode Triggered by Chemical Inputs Processed Through a Biocatalytic Cascade – Integration of Biomolecular Computing and Actuation / Andrey V. Okhokhonin, Sergii Domanskyi, Yaroslav Filipov, Maria Gamella, Alisa N. Kozitsina, Vladimir Privman, and Evgeny Katz // Electroanalysis. – 2018. - V. 30. – P. 426 – 435.
· Sensors based on bio and biomimetic receptors in medical diagnostic, environment, and food analysis / Kozitsina A.N. Svalova T.S., Malysheva N.N., Okhokhonin A.V., Vidrevich, M.B., Brainina, K.Z. // Biosensors. – 2018. - V. 8. – №. 35.
· Pat. 2507512 of the Russian Federation. IPC G01N27 / 30. A method of manufacturing a modified electrode for electrochemical analysis (options) / N.A. Malakhova, A.V. Ivanova, A.N. Kozitsina, S.Yu. Sarajevo, J.V. Shalygina, L.I. Kolyadina, A.V. Ohokhonin, A.I. Mathern; declare 04.06.2012: publ. 02.20.2014, bul. No. 5
· Pat. 2612143 of the Russian Federation. Method for determination of bacterial content using modified magnetic nanoparticles as a label / A.N. Kozitsina,TS Svalova, Yu.A. Glazyrina, A.I. Mathern; declare 07.27.2015: publ 02.03. 2017, bul. No. 7
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Created / Updated: 24 March 2019 / 9 February 2022
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